Connotation, for everyone in the fall?

The booster vaccine reduces severe forms of COVID-19 by boosting the immune system. “There will be a suggestion of an additional dose before the fall,” Professor Arnaud Fontanet estimated on May 4. Who is today? For whom in the fall? Mandatory at age 60?

[Mis à jour le 5 mai 2022 à 12h38] The vaccination more breakable Confrontation COVID-19 It must continue even if The epidemic is decreasing in France. The The fourth dose of the vaccine (corresponding to a second booster dose) open 60-year-old French And more for all patients Immunocompromised. “The Israeli data It turns out that for those over 60 years old The fourth dose is divided by 4 risks of hospitalization, So there is a Real effect on extreme shapes And there No more side effects after the third dose Nor depletion of the immune response upon repeated injections. Professor Arnaud Fontanet points out in France 5 on May 4th. “So there is no reason to refuse a fourth dose. Now there is real fatigue. We can clearly see that this Fourth dose do not take. It is true that with the decline in wave BA.2, people are telling themselves that eventually vaccinating now may not helpAdds an epidemiologist from the Pasteur Institute. “What is almost certain is that there will be a file Strong suggestion for an extra dose just before the onset of fall Since we know there may be a resumption of the pandemic, that will be a concern for the over-60s population. Will you transcend, meaning for the youngestwe don’t know yet. It really depends on the state of the epidemic. at this momentHe defended Professor Arnaud Fontanet. We are not ruling out until the start of the school year“, in September, It is necessary to return a fourth dose to the entire population, but we will see at that time according to the variables that will be generalized“, Professor Bruno Megarban, head of the intensive care unit at Lariboisière Hospital in Paris, announced on April 24 on the Franceinfo website. “As of April 25, among the 60 – 79 years, 3.3% He received a second booster. in between 80 years and overThe vaccination coverage was with the second booster dose 13.2%“Saint-Public informs France in its epidemiological update on April 28 an appointment open (possibility to have it Doctolip) and the vaccination It can be done at a vaccination center, pharmacy, clinic, or at home. Who has to do 4 doses today in France? is she Is mandatory ? What are the indications and recommendations? How long after the third injection? ? With which vaccine? Pfizer or Moderna?

The fourth dose of the Covid vaccine: for whom?

Since April 7, A . has been injected The fourth dose of the coronavirus vaccine is available to people over the age of 60 who were 6 months or more away from their first booster dose (or last infection with COVID). This second summoning was already open to French people aged 80 and over All patients who received their booster dose more than 3 months ago Immunocompromised (No longer just “severe immunodeficiency”). According to the November 2021 COSV opinion, the severely immunocompromised persons concerned with the fourth dose are:

  • solid organ transplant recipients,
  • recent bone marrow transplant recipients,
  • dialysis patients,
  • Patients with autoimmune diseases who are undergoing aggressive immunosuppressive therapy such as anti-CD20 or anti-metabolics,
  • Patients with certain types of lymphoma who have been treated with anti-CD20 or BTK inhibitors,
  • patients with chronic lymphocytic leukemia,
  • Patients with rare forms of primary immunodeficiency,
  • Myeloma under treatment

“As of April 18, 2022, among those aged 80 and over, The coverage rate of the second booster vaccination was 11.2%. And 17.4% of those who were eligible by that date had obtained it. in between 60 – 79 years, 2.7% received a second booster dose (28.8% among those eligible in this age group)” It reveals public health in France on April 21.

What does HAS recommend for the fourth dose?

The Supreme Health Authority recommends a fourth dose of the vaccinePeople 65 years of age or older, are at high risk of developing acute illness and/or multiple illnesses And who so desires, within the framework of a medical decision that is shared with their healthcare team, taking into account their individual medical condition“.

Since vaccine efficacy remains good (more than 70% hospitalized) 3 months after the first booster dose, HAS recommends that in the case of the second reinforcement, it is preferable to respect a period of at least 6 months with the first reinforcer. The Authority notesThat due to still limited data on the protection conferred by Omicron infection, there is no No need to consider a second booster dose in people with recent SARS-CoV-2 infection With this variable, regardless of their age”.

Is the fourth dose mandatory?

Fourth dose of corona virus vaccine Not mandatory butopened“, Yes, this is possible to Persons over 60 years of age who are 6 months or older from their first reminder, People who are at least 80 years old and for all immunocompromised patients (from 3 months after the first booster dose). So the fourth dose is not Not required.

A fourth dose for everyone at the beginning of the school year in September?

In the opinion of many clinicians, a fourth dose of the vaccine (the second booster) is expected to be offered to the entire French population (adults) at the beginning of the school year. This is in light of the possibility of the epidemic resuming in the fall and because the date of the last dose has exceeded 6 months for the majority of vaccinated people. “there will be Strong suggestion for an extra dose just before the onset of fall Since we know there may be a resumption of the pandemic, that will be a concern for the over-60s population. We don’t yet know if he’ll ever get past it, that is, for the youngest of them all. It really depends on The epidemiological situation at that time He defended Professor Arnaud Fontanet on May 5. We are not ruling out until the start of the school year“, in September, It is necessary to return a fourth dose to the entire population, but we will see at that time according to the variables that will be generalized“, Professor Bruno Megarban also presented on April 24 on Franceinfo.

what he does Vaccine production laboratories ? Stefan Bancel, CEO of Modernaduring a press conference on January 6 that a fourth dose of the Covid vaccine will likely be necessary:I still think so We’ll need Fall 2022 boosters And on top of all that.Albert Burla, CEO of Pfizeron BFM-TV on Mondays January 17: “At the moment, it is important to get three doses for a full vaccination, Possibly a fourth dose shortly thereafter for the general population

How effective is the fourth dose?

The The fourth dose is divided by 4 risks of hospitalization, So there is a Real effect on extreme shapes And there No more side effects after the third dose Nor depletion of the immune response upon repeated injections. Refers to Professor Arnaud Fontanet on May 5th. “It is known that the second booster vaccination [ou quatrième dose] Reduces the risk of hospitalization, resuscitation and death by 80%“Olivier Veran announced on April 7th on RTL”.After a booster injection with the Pfizer vaccine, Vaccine efficacy against hospitalization was 90% and decreased to approximately 85% after 5-9 weeks and then 75% after 10-14 weeks.. After using Moderna’s booster vaccine, the enhanced efficacy against hospitalization was 90-95% up to 9 weeks after vaccination HAS indicated in its opinion issued on 17 March 2022.

How long does it take to take the fourth dose?

► From 60 to 79 years old: Starting from 6 months and over From the first booster dose or from 6 months after the last infection.

For people who have already contracted Covid after their first reminder:

  • If infection occurs more than 3 months after the first dose, a A second reminder is not necessary.
  • If infection occurs less than 3 months after the first dose, a second booster dose is necessary. You must then wait at least 6 months after the injury before receiving your second booster dose.

► From the age of 80 and for people with immunodeficiency: The fourth dose of the vaccine is for those who have since received their booster dose More than 3 months.

► In people with severe immunodeficiency, The fourth dose of the vaccine is part of the complete basic vaccination schedule. They can then make a recall regarding medical advice. she Performed a month after the third dose.

Moderna vs. Pfizer: Which Vaccine for the Fourth Dose?

The booster dose is carried out for eligible persons Only with the mRNA vaccine, either Pfizer (30 mcg dose) or Moderna (50 mcg dose) regardless of the vaccine(s) used previously according to COSV. The Pfizer vaccine is the only vaccine recommended for people under 30 years of age. “Full dose of Pfizer-BioNTech vaccine or half dose of Moderna vaccine Used in this second booster shotDGS recommends.

What results from the fourth dose in Israel?

Israel started on January 3, 2022 time fourth dose injectionFor people over 60 years old and more, Medical staff and workers in health and social protection institutions, in addition to people who have been immunocompromised since December 31, according to the country’s Ministry of Health. “The Israeli data It turns out that for those over 60 years old The fourth dose is divided by 4 risks of hospitalization, So there is a Real effect on extreme shapes And there No more side effects after the third dose Nor depletion of the immune response upon repeated injections. Professor Arnaud Fontanet points out in France 5 on May 4th.

sources:

Recommendations of the Vaccines Strategy Guidelines Council to Protect Persons with Severe Immunodeficiency Against Covid-19 (Vaccination and Primary Prevention) – 19 November 2021

Launch of Booster Vaccine Campaign Against Covid-19 for Priority Population – DGS – 27 August 2021

Vaccine Strategy Advisory Board opinion on August 19, 2021 – Minimum time between primary and booster vaccination

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